Christina Tague's research is focused on the interactions between hydrology and ecosystem processes and, specifically, how eco-hydrologic systems are altered by changes in land use and climate. Much of her work involves developing and using spatial simulation models to integrate data from multiple field-based monitoring studies in order to generalize results to larger watersheds. Reflecting that emphasis, she is one of the principal developers of the Regional Hydro-Ecologic Simulation System (RHESSys), an integrated model of spatially distributed carbon, water, and nitrogen cycling.